Name: Chromium Trioxide
CAS: 1333-82-0
EC Number: 215-607-8
Chemical Formular: CrO3
Appearance: Dark red granular solid
Molecular Weight: 99.994 g/mol
Melting Point: 197 °C (387 °F; 470 K)
Boiling Point: 250 °C (482 °F; 523 K)
Density: 2.7 g/cm3 (20 °C)
Solubility in water: 169 g/100 mL
Exact Mass: 99.925249 g/mol
Monoisotopic Mass: 99.925249 g/mol
Topological Polar Surface Area: 51.2 A^2
Complexity: 61.8

Chromium Trioxide
99% Chromium Trioxide
99.5% Chromium Trioxide
99.9% Chromium Trioxide
99.95% Chromium Trioxide
99.99% Chromium Trioxide
99.999% Chromium Trioxide
Chromium Trioxide,customized specifications


According to the UN GHS revision 8

Version: 1.0

Creation Date: Nov 17, 2020

Revision Date: Nov 17, 2020

SECTION 1: Identification


GHS Product identifier

Product name

Chromium Trioxide


Other means of identification

Product number

Other names

Chromic anhydride;Chromium Oxide;CROMIUM TRIOXIDE


Recommended use of the chemical and restrictions on use

Identified uses

Corrosion inhibitors and anti-scaling agents,Plating agents and surface treating agents,Processing aids, specific to petroleum production

Uses advised against

no data available


Supplier’s details


Elements China Limited


Building 2, No.5555, Shenzhuan Hwy, Shanghai , China



1.5Emergency phone number

Emergency phone number


Service hours

Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

SECTION 2: Hazard identification


Classification of the substance or mixture

Oxidizing solids, Category 1

Acute toxicity – Category 3, Oral

Acute toxicity – Category 3, Dermal

Skin corrosion, Sub-category 1A

Skin sensitization, Category 1

Acute toxicity – Category 2, Inhalation

Respiratory sensitization, Category 1

Germ cell mutagenicity, Category 1B

Carcinogenicity, Category 1A

Specific target organ toxicity – repeated exposure, Category 1

Hazardous to the aquatic environment, short-term (Acute) – Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) – Category Chronic 1

Reproductive toxicity, Category 2


GHS label elements, including precautionary statements


Signal word


Hazard statement(s)

H271 May cause fire or explosion; strong oxidizer

H301 Toxic if swallowed

H311 Toxic in contact with skin

H314 Causes severe skin burns and eye damage

H317 May cause an allergic skin reaction

H330 Fatal if inhaled

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

H340 May cause genetic defects

H350 May cause cancer

H372 Causes damage to organs through prolonged or repeated exposure

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P220 Keep away from clothing and other combustible materials.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…

P283 Wear fire resistant or flame retardant clothing.

P264 Wash … thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.


P306+P360 IF ON CLOTHING: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.

P371+P380+P375 In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.

P370+P378 In case of fire: Use … to extinguish.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see … on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/…

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P333+P317 If skin irritation or rash occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P320 Specific treatment is urgent (see … on this label).

P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.

P318 IF exposed or concerned, get medical advice.

P319 Get medical help if you feel unwell.

P391 Collect spillage.


P420 Store separately.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.


P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.


Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients



Chemical nameCommon names and synonymsCAS numberEC number
Chromium TrioxideChromium trioxide1333-82-0215-607-8

SECTION 4: First-aid measures


Description of necessary first-aid measures

If inhaled

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Following skin contact

Remove contaminated clothes. First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention.


Most important symptoms/effects, acute and delayed

Very irritating to eyes and respiratory tract. Ingestion causes severe gastrointestinal symptoms. Contact with eyes or skin causes burns; prolonged contact produces dermatitis (“chrome sores”). (USCG, 1999)


Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Inorganic Acids and Related Compounds

SECTION 5: Fire-fighting measures


Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.


Specific hazards arising from the chemical

Behavior in Fire: Containers may explode (USCG, 1999)


Special protective actions for fire-fighters

NO water. In case of fire in the surroundings, use appropriate extinguishing media.

SECTION 6: Accidental release measures


Personal precautions, protective equipment and emergency procedures

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.


Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.


Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided; Methods and materials for containment and cleaning up: Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wetbrushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

SECTION 7: Handling and storage


Precautions for safe handling

NO contact with combustible substances or reducing agents.
Handling in a well ventilated place.
Wear suitable protective clothing.
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.
Use non-sparking tools.
Prevent fire caused by electrostatic discharge steam.


Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Separated from combustible substances, reducing agents, bases and food and feedstuffs. Well closed. Store in an area without drain or sewer access.Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Heat sensitive. Storage class (TRGS 510): Strongly oxidizing hazardous materials

SECTION 8: Exposure controls/personal protection


Control parameters

Occupational Exposure limit values

TLV: (as Cr(VI), inhalable fraction): 0.0002 mg/m3, as TWA; 0.0005 mg/m3 as STEL; A1 (confirmed human carcinogen); (skin); (DSEN); (RSEN).EU-OEL: (as Cr): 0.1 mg/m3 as TWA.MAK: (inhalable fraction): skin absorption (H); sensitization of skin (SH); carcinogen category: 1; germ cell mutagen group: 2

Biological limit values

no data available


Appropriate engineering controls

Ensure adequate ventilation.
Handle in accordance with good industrial hygiene and safety practice.
Set up emergency exits and the risk-elimination area.

8.3Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear face shield or eye protection in combination with breathing protection.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use closed system or ventilation.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state

Solid. Deliquescent crystals, flakes or powder.


Dark red.



Melting point/freezing point

196 °C.

Boiling point or initial boiling point and boiling range

Remarks:Decomposition products are Cr2 O3 and O2.


CrO3: Noncombustible Solid, but will accelerate the burning of combustible materials.

Lower and upper explosion limit/flammability limit

no data available

Flash point


Auto-ignition temperature

May ignite organic materials on contact. (USCG, 1999)

Decomposition temperature



Dissolves in water to form a weak acid

Kinematic viscosity

no data available


Miscible with water

Partition coefficient n-octanol/water

no data available

Vapour pressure

Very low (NIOSH, 2016)

Density and/or relative density

Ca. 2.7 g/cm³.

Relative vapour density

no data available

Particle characteristics

no data available

SECTION 10: Stability and reactivity



250 mg/cu m (as Cr(II)). Chromium(II) compounds (as Cr)

25 mg/cu m (as Cr(III)). Chromium(III) compounds (as Cr)

15 mg/cu m (as Cr(VI)). Chromic acid and chromates

NIOSH considers chromic acid and chromates to be potential occupational carcinogens. Chromic acid and chromates

Decomposes above 250°C . This produces chromic oxide and oxygen. This increases fire hazard. The substance is a strong oxidant. It reacts violently with combustible and reducing materials. This generates fire and explosion hazard. The solution in water is a strong acid. It reacts violently with bases and is corrosive.


Chemical stability

Stable under recommended storage conditions.


Possibility of hazardous reactions

Powerful oxidizer … contact with combustible material may cause fire.CHROMIUM TRIOXIDE is a powerful oxidizing agent. Can react violently upon contact with reducing reagents, including organic matter, leading to ignition or explosion. Dangerously reactive with acetone, alcohols, alkali metals (sodium, potassium), ammonia, arsenic, dimethylformamide, hydrogen sulfide, phosphorus, peroxyformic acid, pyridine, selenium, sulfur, and many other chemicals [Sax, 9th ed., 1996, p. 852]. Noncombustible but can accelerate the burning of combustible materials. Sufficient heat may be generated from the reaction with combustible materials to ignite the mass. Aqueous solutions corrode many metals rapidly. Often mixed with sulfuric acid to make “cleaning solution” for glass. Used cleaning solution in closed bottles may explode due to the build up of gaseous carbon dioxide arising from oxidation of organic impurities [Bryson, W. R., Chem. Brit., 1975, 11, p. 377].


Conditions to avoid

no data available


Incompatible materials

Incompatible materials: Organic materials, Phosphorus, powdered metals.


Hazardous decomposition products

Decomposes when heated to 250 deg C, liberating oxygen to support combustion.

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 – rat (male/female) – 52 mg/kg bw.
  • Inhalation: LC50 – rat (male) – 104 mg/m³ air.
  • Dermal: LD50 – rabbit (male/female) – 57 mg/kg bw.

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


WEIGHT OF EVIDENCE CHARACTERIZATION: Under the current guidelines (1986), Cr(VI) is classified as Group A – known human carcinogen by the inhalation route of exposure. Carcinogenicity by the oral route of exposure cannot be determined and is classified as Group D. Under the proposed guidelines (1996), Cr(VI) would be characterized as a known human carcinogen by the inhalation route of exposure on the following basis. Hexavalent chromium is known to be carcinogenic in humans by the inhalation route of exposure. Results of occupational epidemiological studies of chromium-exposed workers are consistent across investigators and study populations. Dose-response relationships have been established for chromium exposure and lung cancer. Chromium-exposed workers are exposed to both Cr(III) and Cr(VI) compounds. Because only Cr(VI) has been found to be carcinogenic in animal studies, however, it was concluded that only Cr(VI) should be classified as a human carcinogen. Animal data are consistent with the human carcinogenicity data on hexavalent chromium. Hexavalent chromium compounds are carcinogenic in animal bioassays, producing the following tumor types: intramuscular injection site tumors in rats and mice, intrapleural implant site tumors for various Cr(VI) compounds in rats, intrabronchial implantation site tumors for various Cr(VI) compounds in rats and subcutaneous injection site sarcomas in rats. In vitro data are suggestive of a potential mode of action for hexavalent chromium carcinogenesis. Hexavalent chromium carcinogenesis may result from the formation of mutagenic oxidatitive DNA lesions following intracellular reduction to the trivalent form. Cr(VI) readily passes through cell membranes and is rapidly reduced intracellularly to generate reactive Cr(V) and Cr(IV) intermediates and reactive oxygen species. A number of potentially mutagenic DNA lesions are formed during the reduction of Cr(VI). Hexavalent chromium is mutagenic in bacterial assays, yeasts and V79 cells, and Cr(VI) compounds decrease the fidelity of DNA synthesis in vitro and produce unscheduled DNA synthesis as a consequence of DNA damage. Chromate has been shown to transform both primary cells and cell lines. HUMAN CARCINOGENICITY DATA: Occupational exposure to chromium compounds has been studied in the chromate production, chromeplating and chrome pigment, ferrochromium production, gold mining, leather tanning and chrome alloy production industries. Workers in the chromate industry are exposed to both trivalent and hexavalent compounds of chromium. Epidemiological studies of chromate production plants in Japan, Great Britain, West Germany, and the United States have revealed a correlation between occupational exposure to chromium and lung cancer, but the specific form of chromium responsible for the induction of cancer was not identified … Studies of chrome pigment workers have consistently demonstrated an association between occupational chromium exposure (primarily Cr(VI)) and lung cancer. Several studies of the chromeplating industry have demonstrated a positive relationship between cancer and exposure to chromium compounds. ANIMAL CARCINOGENICITY DATA: Animal data are consistent with the findings of human epidemiological studies of hexavalent chromium … Chromium (VI)

Reproductive toxicity

no data available

STOT-single exposure

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. The substance may cause effects on the kidneys and liver. This may result in tissue lesions.

STOT-repeated exposure

Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. Repeated or prolonged inhalation may cause nasal ulceration. This may result in perforation of the nasal septum. The substance may have effects on the kidneys. This may result in kidney impairment. This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

Aspiration hazard

A harmful concentration of airborne particles can be reached quickly when dispersed.

SECTION 12: Ecological information



  • Toxicity to fish: Range of species tested.
  • Toxicity to daphnia and other aquatic invertebrates: Range of species tested.
  • Toxicity to algae: Range of species tested.
  • Toxicity to microorganisms: Range of microbes reported.


Persistence and degradability

Biological oxygen demand (BOD): none


Bioaccumulative potential

Using carp (Cyprinus carpio) which were exposed over a 6-week period to chromic trioxide concentrations of 1, 5, 20 and 100 ppb (measured as chromium), the chromium BCF ranged from 4.6 to 72(1). According to a classification scheme(2), this BCF range suggests the potential for bioconcentration in aquatic organisms is low to moderate(SRC).


Mobility in soil

no data available


Other adverse effects

no data available

SECTION 13: Disposal considerations


Disposal methods


The material can be disposed of by removal to
a licensed chemical destruction plant or by controlled incineration
with flue gas scrubbing. Do not contaminate water, foodstuffs,
feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and
offered for recycling or reconditioning.
Alternatively, the packaging can be punctured to
make it unusable for other purposes and then be disposed of
in a sanitary landfill. Controlled incineration
with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information


UN Number

ADR/RID: UN1463 (For reference only, please check.)IMDG: UN1463 (For reference only, please check.)IATA: UN1463 (For reference only, please check.)


UN Proper Shipping Name

ADR/RID: CHROMIUM TRIOXIDE, ANHYDROUS (For reference only, please check.)IMDG: CHROMIUM TRIOXIDE, ANHYDROUS (For reference only, please check.)IATA: CHROMIUM TRIOXIDE, ANHYDROUS (For reference only, please check.)


Transport hazard class(es)

ADR/RID: 5.1 (For reference only, please check.)IMDG: 5.1 (For reference only, please check.)IATA: 5.1 (For reference only, please check.)


Packing group, if applicable

ADR/RID: II (For reference only, please check.)IMDG: II (For reference only, please check.)IATA: II (For reference only, please check.)


Environmental hazards



Special precautions for user

no data available


Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information


Safety, health and environmental regulations specific for the product in question

Chemical nameCommon names and synonymsCAS numberEC number
Chromium TrioxideChromium trioxide1333-82-0215-607-8
European Inventory of Existing Commercial Chemical Substances (EINECS)Listed.
EC InventoryListed.
United States Toxic Substances Control Act (TSCA) InventoryListed.
China Catalog of Hazardous chemicals 2015Listed.
New Zealand Inventory of Chemicals (NZIoC)Listed.
Philippines Inventory of Chemicals and Chemical Substances
Vietnam National Chemical InventoryListed.
Chinese Chemical Inventory of Existing Chemical Substances (China
Korea Existing Chemicals List (KECL)Listed.

SECTION 16: Other information

Information on revision

Creation DateNov 17, 2020
Revision DateNov 17, 2020

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS – The International Chemical Safety Cards (ICSC), website:
  • HSDB – Hazardous Substances Data Bank, website:
  • IARC – International Agency for Research on Cancer, website:
  • eChemPortal – The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG – Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA – European Chemicals Agency, website:

Other Information

Do NOT take working clothes home.Rinse contaminated clothing with plenty of water because of fire hazard.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.Depending on the degree of exposure, periodic medical examination is suggested.

Any questions regarding this SDS, Please send your inquiry to [email protected]

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information in this document is based on the present state of our
knowledge and is applicable to the product with regard to appropriate safety precautions. It does not
represent any guarantee of the properties of the product. We as supplier shall not be held liable for any
damage resulting from handling or from contact with the above product.

Chemical Formular:CrO3
PubChem CID:14915
IUPAC Name:trioxochromium
Canonical SMILES:O=[Cr](=O)=O
Globally Harmonized System of Classification
Globally Harmonized System of Classification
Globally Harmonized System of Classification
Globally Harmonized System of Classification
Globally Harmonized System of Classification
GHS Hazard Statements:H271-H301-H311-H314-H317-H330-H334-H340-H350-H361f-H372-H410
Hazard Codes:O,T+,N
Risk Codes:R45-46-9-24/25-26-35-42/43-48/23-50/53-62
Precautionary Statement Codes:P201-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Flash Point:n/a

Chromium(VI) Oxide
Monochromium trioxide
Chromium(6+) oxide

Chromium anhydride
chromic trioxide

ChromiumChromium is a chemical element with the symbol Cr and atomic number 24. It is the first element in group 6.
It is a steely-grey, lustrous, hard and brittle transition metal.
Chromium is also the main additive in stainless steel, to which it adds anti-corrosive properties.
Chromium is also highly valued as a metal that is able to be highly polished while resisting tarnishing. Polished chromium reflects almost 70% of the visible spectrum, with almost 90% of infrared light being reflected.
The name of the element is derived from the Greek word χρῶμα, chrōma, meaning color, because many chromium compounds are intensely colored.
Chromium is a naturally occurring element found in rocks, animals, plants, soil, and in volcanic dust and gases. Chromium is present in the environment in several different forms. The most common forms are chromium(0), chromium(III), and chromium(VI).
No taste or odor is associated with chromium compounds. Chromium(III) occurs naturally in the environment and is an essential nutrient.
Chromium(VI) and chromium(0) are generally produced by industrial processes.
The metal chromium, which is the chromium(0) form, is used for making steel. Chromium(VI) and chromium(III) are used for chrome plating, dyes and pigments, leather tanning, and wood preserving.

OxygenOxygen is the chemical element with the symbol O and atomic number 8, meaning its nucleus has 8 protons.
Oxygen is a member of the chalcogen group on the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as well as with other compounds.
Dioxygen is used in cellular respiration and many major classes of organic molecules in living organisms contain oxygen, such as proteins, nucleic acids, carbohydrates, and fats, as do the major constituent inorganic compounds of animal shells, teeth, and bone.
Oxygen was isolated by Michael Sendivogius before 1604, but it is commonly believed that the element was discovered independently by Carl Wilhelm Scheele, in Uppsala, in 1773 or earlier, and Joseph Priestley in Wiltshire, in 1774.

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